I do agree with what the person above me said - sort of. I think Publisher or FrontPage may be good depending on your level of knowledge. Dreamweaver is a great tool but really complicated.

Depending on what you're trying to do with the website, you may not need standalone software. You may consider getting a solution that has a site builder with it - that way you can call the company for help and you will have everything in one place. You can check out Yahoo or my signature link for pageBuzz.

If you're going to go with software, then I would recommend getting something as simple as possible especially if you're just getting started. Better yet, you may want to go to Barnes&Noble and see what books they have available - something to walk you through using the software and using FTP or CPanel to upload the site to your Web Hosting service provider.